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CYP1A1基因Ile462Val多态位点在吸烟人群中与肺癌易感性显著相关

蔡燕燕 谭晓明 郑红霞 顾海英 詹晓莹 吴奇涵

蔡燕燕, 谭晓明, 郑红霞, 顾海英, 詹晓莹, 吴奇涵. CYP1A1基因Ile462Val多态位点在吸烟人群中与肺癌易感性显著相关[J]. 华东师范大学学报(自然科学版), 2011, (4): 115-123.
引用本文: 蔡燕燕, 谭晓明, 郑红霞, 顾海英, 詹晓莹, 吴奇涵. CYP1A1基因Ile462Val多态位点在吸烟人群中与肺癌易感性显著相关[J]. 华东师范大学学报(自然科学版), 2011, (4): 115-123.
CAI Yan-yan, TAN Xiao-ming, ZHENG Hong-xia, GU Hai-ying, ZHAN Xiao-ying, WU Qi-han. Meta-analysis of CYP1A1 polymorphisms and lung cancer risk among smokers[J]. Journal of East China Normal University (Natural Sciences), 2011, (4): 115-123.
Citation: CAI Yan-yan, TAN Xiao-ming, ZHENG Hong-xia, GU Hai-ying, ZHAN Xiao-ying, WU Qi-han. Meta-analysis of CYP1A1 polymorphisms and lung cancer risk among smokers[J]. Journal of East China Normal University (Natural Sciences), 2011, (4): 115-123.

CYP1A1基因Ile462Val多态位点在吸烟人群中与肺癌易感性显著相关

详细信息
  • 中图分类号: R734.2

Meta-analysis of CYP1A1 polymorphisms and lung cancer risk among smokers

  • 摘要: 利用meta分析的方法探讨吸烟人群中CYP1A1基因多态位点与肺癌易感性的关系.获取1986年至2010年2月pubmed等数据库中有关CYP1A1基因Ile462Val和Msp1位点多态性与肺癌易感性关系的研究结果,统计对应的吸烟者或非吸烟者的研究数据,运用RevMan 4.2软件对各研究原始结果进行统计处理,计算合并OR值及95%可信区间.按照纳入标准,最终入选文献共有29篇病例对照研究,吸烟者中Ile462Val位点与肺癌发生显著相关, 基因型Val/Val+Ile/Val 比 Ile/Ile的合并OR值为1.29(95%CI∶1.03,1.63),P0.05,而该位点在非吸烟者中及Msp1位点在两种人群的分析结果均不具统计学意义.上述结果提示,对目前相关研究结果的Meta分析显示,吸烟者中CYP1A1基因Ile462Val位点多态性与肺癌易感性之间存在一定相关性.
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  • 收稿日期:  2010-05-01
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  • 刊出日期:  2011-07-05

CYP1A1基因Ile462Val多态位点在吸烟人群中与肺癌易感性显著相关

  • 中图分类号: R734.2

摘要: 利用meta分析的方法探讨吸烟人群中CYP1A1基因多态位点与肺癌易感性的关系.获取1986年至2010年2月pubmed等数据库中有关CYP1A1基因Ile462Val和Msp1位点多态性与肺癌易感性关系的研究结果,统计对应的吸烟者或非吸烟者的研究数据,运用RevMan 4.2软件对各研究原始结果进行统计处理,计算合并OR值及95%可信区间.按照纳入标准,最终入选文献共有29篇病例对照研究,吸烟者中Ile462Val位点与肺癌发生显著相关, 基因型Val/Val+Ile/Val 比 Ile/Ile的合并OR值为1.29(95%CI∶1.03,1.63),P0.05,而该位点在非吸烟者中及Msp1位点在两种人群的分析结果均不具统计学意义.上述结果提示,对目前相关研究结果的Meta分析显示,吸烟者中CYP1A1基因Ile462Val位点多态性与肺癌易感性之间存在一定相关性.

English Abstract

蔡燕燕, 谭晓明, 郑红霞, 顾海英, 詹晓莹, 吴奇涵. CYP1A1基因Ile462Val多态位点在吸烟人群中与肺癌易感性显著相关[J]. 华东师范大学学报(自然科学版), 2011, (4): 115-123.
引用本文: 蔡燕燕, 谭晓明, 郑红霞, 顾海英, 詹晓莹, 吴奇涵. CYP1A1基因Ile462Val多态位点在吸烟人群中与肺癌易感性显著相关[J]. 华东师范大学学报(自然科学版), 2011, (4): 115-123.
CAI Yan-yan, TAN Xiao-ming, ZHENG Hong-xia, GU Hai-ying, ZHAN Xiao-ying, WU Qi-han. Meta-analysis of CYP1A1 polymorphisms and lung cancer risk among smokers[J]. Journal of East China Normal University (Natural Sciences), 2011, (4): 115-123.
Citation: CAI Yan-yan, TAN Xiao-ming, ZHENG Hong-xia, GU Hai-ying, ZHAN Xiao-ying, WU Qi-han. Meta-analysis of CYP1A1 polymorphisms and lung cancer risk among smokers[J]. Journal of East China Normal University (Natural Sciences), 2011, (4): 115-123.
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