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NR1基因敲除对小鼠前额叶脑区LTP的影响

杨李果 曾庆文 张旭亮 曹晓华

杨李果, 曾庆文, 张旭亮, 曹晓华. NR1基因敲除对小鼠前额叶脑区LTP的影响[J]. 华东师范大学学报(自然科学版), 2012, (1): 47-53.
引用本文: 杨李果, 曾庆文, 张旭亮, 曹晓华. NR1基因敲除对小鼠前额叶脑区LTP的影响[J]. 华东师范大学学报(自然科学版), 2012, (1): 47-53.
YANG Li-guo, ZENG Qing-wen, ZHANG Xu-liang, CAO Xiao-hua. Long-term potentiation of prefrontal cortex in NR1 knockout mice[J]. Journal of East China Normal University (Natural Sciences), 2012, (1): 47-53.
Citation: YANG Li-guo, ZENG Qing-wen, ZHANG Xu-liang, CAO Xiao-hua. Long-term potentiation of prefrontal cortex in NR1 knockout mice[J]. Journal of East China Normal University (Natural Sciences), 2012, (1): 47-53.

NR1基因敲除对小鼠前额叶脑区LTP的影响

详细信息
  • 中图分类号: Q189

Long-term potentiation of prefrontal cortex in NR1 knockout mice

  • 摘要: 用前脑特异性NR1基因敲除小鼠,采用离体脑片场电位技术,研究了NR1亚基在前额叶脑区突触可塑性中的作用.刺激强度反应(input-output curve)和双脉冲抑制反应(paired pulse depression, PPD)的结果表明,与同窝对照组小鼠相比,NR1基因敲除小鼠前额叶脑区的基本突触传递无明显变化.采用高频刺激(100 Hz, 1 000 ms 2, 间隔30 s)在小鼠的前额叶脑区诱导长时程增强(long-term potentiation, LTP),与对照组小鼠相比,NR1基因敲除小鼠前额叶脑区的LTP明显受损.以上数据提示,NR1亚基在前额叶脑区LTP的诱导中起着重要的作用.
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出版历程
  • 收稿日期:  2011-02-01
  • 修回日期:  2011-05-01
  • 刊出日期:  2012-01-25

NR1基因敲除对小鼠前额叶脑区LTP的影响

  • 中图分类号: Q189

摘要: 用前脑特异性NR1基因敲除小鼠,采用离体脑片场电位技术,研究了NR1亚基在前额叶脑区突触可塑性中的作用.刺激强度反应(input-output curve)和双脉冲抑制反应(paired pulse depression, PPD)的结果表明,与同窝对照组小鼠相比,NR1基因敲除小鼠前额叶脑区的基本突触传递无明显变化.采用高频刺激(100 Hz, 1 000 ms 2, 间隔30 s)在小鼠的前额叶脑区诱导长时程增强(long-term potentiation, LTP),与对照组小鼠相比,NR1基因敲除小鼠前额叶脑区的LTP明显受损.以上数据提示,NR1亚基在前额叶脑区LTP的诱导中起着重要的作用.

English Abstract

杨李果, 曾庆文, 张旭亮, 曹晓华. NR1基因敲除对小鼠前额叶脑区LTP的影响[J]. 华东师范大学学报(自然科学版), 2012, (1): 47-53.
引用本文: 杨李果, 曾庆文, 张旭亮, 曹晓华. NR1基因敲除对小鼠前额叶脑区LTP的影响[J]. 华东师范大学学报(自然科学版), 2012, (1): 47-53.
YANG Li-guo, ZENG Qing-wen, ZHANG Xu-liang, CAO Xiao-hua. Long-term potentiation of prefrontal cortex in NR1 knockout mice[J]. Journal of East China Normal University (Natural Sciences), 2012, (1): 47-53.
Citation: YANG Li-guo, ZENG Qing-wen, ZHANG Xu-liang, CAO Xiao-hua. Long-term potentiation of prefrontal cortex in NR1 knockout mice[J]. Journal of East China Normal University (Natural Sciences), 2012, (1): 47-53.
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