中国综合性科技类核心期刊(北大核心)

中国科学引文数据库来源期刊(CSCD)

美国《化学文摘》(CA)收录

美国《数学评论》(MR)收录

俄罗斯《文摘杂志》收录

留言板

尊敬的读者、作者、审稿人, 关于本刊的投稿、审稿、编辑和出版的任何问题, 您可以本页添加留言。我们将尽快给您答复。谢谢您的支持!

姓名
邮箱
手机号码
标题
留言内容
验证码

前脑特异性过表达NR2B基因对小鼠社会互动能力的影响

张宁 李春霞

张宁, 李春霞. 前脑特异性过表达NR2B基因对小鼠社会互动能力的影响[J]. 华东师范大学学报(自然科学版), 2012, (4): 75-82.
引用本文: 张宁, 李春霞. 前脑特异性过表达NR2B基因对小鼠社会互动能力的影响[J]. 华东师范大学学报(自然科学版), 2012, (4): 75-82.
ZHANG Ning, LI Chun-xia. Effect of forebrain NR2B overexpression on social interactions in transgenic mice[J]. Journal of East China Normal University (Natural Sciences), 2012, (4): 75-82.
Citation: ZHANG Ning, LI Chun-xia. Effect of forebrain NR2B overexpression on social interactions in transgenic mice[J]. Journal of East China Normal University (Natural Sciences), 2012, (4): 75-82.

前脑特异性过表达NR2B基因对小鼠社会互动能力的影响

详细信息
  • 中图分类号: Q189

Effect of forebrain NR2B overexpression on social interactions in transgenic mice

  • 摘要: 将2~3月龄实验小鼠分为前脑NR2B过表达的转基因雌性和雄性小鼠以及同窝野生对照雌性和雄性小鼠,进行社会互动能力测试,包括新环境中的社会互动能力测试、社会交往能力和社会新奇偏好测试.结果显示,前脑NR2B表达量的提高,对NR2B转基因小鼠在新环境中的社会互动能力和社会新奇偏好无影响.但是却使得雌性NR2B转基因小鼠的社会交往能力提高,但是对雄性NR2B转基因小鼠却无明显影响.这表明,NR2B在前脑过量表达会提高雌性小鼠的社会交往能力,但对于雄性小鼠社会行为没有明显影响.
  • [1] [1] KUTSUWADA T, KASHIWABUCHI N, MORI H, et al. Molecular diversity of the NMDA receptor channel[J]. Nature, 1992, 358(6381): 36-41.

    [2] MONYER H, SPRENGEL R, SCHOEPFER R, et al. Heteromeric NMDA receptors: molecular and functional distinction of subtypes[J]. Science, 1992, 256(5060): 1217-1221.

    [3] MOHN A R, GAINETDINOV R R, CARON M G, et al. Mice with reduced NMDA receptor expression display behaviors related to schizophrenia[J]. Cell, 1999, 98(4): 427-436.

    [4] HALENE T B, EHRLICHMAN R S, LIANG Y, et al. Assessment of NMDA receptor NR1 subunit hypofunction in mice as a model for schizophrenia[J]. Genes, brain, and behavior, 2009, 8(7): 661-675.

    [5] PECA J, FELICIANO C, TING J T, et al. Shank3 mutant mice display autistic-like behaviours and striatal dysfunction[J]. Nature, 2011, 472(7344): 437-442.

    [6] TANG Y P, SHIMIZU E, DUBE G R, et al. Genetic enhancement of learning and memory in mice[J]. Nature, 1999, 401(6748): 63-69.

    [7] CAO X, CUI Z, FENG R, et al. Maintenance of superior learning and memory function in NR2B transgenic mice during ageing[J]. The European journal of neuroscience, 2007, 25(6): 1815-1822.

    [8] MATSUO N, TANDA K, NAKANISHI K, et al. Comprehensive behavioral phenotyping of ryanodine receptor type 3 (RyR3) knockout mice:decreased social contact duration in two social interaction tests[J]. Frontiers in behavioral neuroscience, 2009(3): 3.

    [9] MOY S S, NADLER J J, PEREZ A, et al. Sociability and preference for social novelty in five inbred strains:an approach to assess autistic-like behavior in mice[J]. Genes Brain Behav, 2004, 3(5): 287-302.

    [10] NADLER J J, MOY S S, DOLD G, et al. Automated apparatus for quantitation of social approach behaviors in mice[J]. Genes Brain Behav, 2004, 3(5): 303-314.

    [11] TANG A C, NAKAZAWA M, ROMEO R D, et al. Effects of long-term estrogen replacement on social investigation and social memory in ovariectomized C57BL/6 mice[J]. Hormones and behavior, 2005, 47(3): 350-357.

    [12] SANCHEZ-ANDRADE G, KENDRICK K M. Roles of alpha- and beta-estrogen receptors in mouse social recognition memory:effects of gender and the estrous cycle[J]. Hormones and behavior, 2011, 59(1): 114-122.
  • 加载中
计量
  • 文章访问数:  1966
  • HTML全文浏览量:  3
  • PDF下载量:  2173
  • 被引次数: 0
出版历程
  • 收稿日期:  2011-04-01
  • 修回日期:  2011-07-01
  • 刊出日期:  2012-07-25

目录

    /

    返回文章
    返回