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早老素PS1/PS2双敲除小鼠中klotho表达的下降和血磷的升高

王栋 翟文珠 苏静静 孟博 赵政 胡金锋

王栋, 翟文珠, 苏静静, 孟博, 赵政, 胡金锋. 早老素PS1/PS2双敲除小鼠中klotho表达的下降和血磷的升高[J]. 华东师范大学学报(自然科学版), 2013, (2): 75-83, 91.
引用本文: 王栋, 翟文珠, 苏静静, 孟博, 赵政, 胡金锋. 早老素PS1/PS2双敲除小鼠中klotho表达的下降和血磷的升高[J]. 华东师范大学学报(自然科学版), 2013, (2): 75-83, 91.
WANG Dong, ZHAI Wen-zhu, SU Jing-jing, MENG Bo, ZHAO Zheng, HU Jin-feng. Decreased klotho expression and elevated blood phosphate level in presenilin PS1/PS2 conditional double knockout mice[J]. Journal of East China Normal University (Natural Sciences), 2013, (2): 75-83, 91.
Citation: WANG Dong, ZHAI Wen-zhu, SU Jing-jing, MENG Bo, ZHAO Zheng, HU Jin-feng. Decreased klotho expression and elevated blood phosphate level in presenilin PS1/PS2 conditional double knockout mice[J]. Journal of East China Normal University (Natural Sciences), 2013, (2): 75-83, 91.

早老素PS1/PS2双敲除小鼠中klotho表达的下降和血磷的升高

详细信息
  • 中图分类号: Q786

Decreased klotho expression and elevated blood phosphate level in presenilin PS1/PS2 conditional double knockout mice

  • 摘要: 为了探讨抗衰老基因klotho是否参与早老素presenilin 1/presenilin 2条件性双敲除(PS cDKO)小鼠的衰老症状,分析了PS cDKO小鼠中肾脏和大脑中klotho的表达.结果发现,与同龄正常对照小鼠相比,12月龄雌性PS cDKO小鼠中肾脏klotho表达明显下降,血磷水平明显升高,而血钙略微下调,但同时几乎没有观察到肾功能障碍;而在大脑中,早在3月龄时klotho水平就已发生下降.这些结果说明klotho可能与PS cDKO小鼠的症状有关,其表达水平的下降可能导致了血磷浓度的上升,但不足以引发肾功能障碍.此外,klotho作为一个抗氧化和抗炎症的因子,其表达下降可能与PS cDKO小鼠体内氧化压力和炎症反应的升高有关.
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出版历程
  • 收稿日期:  2011-12-01
  • 修回日期:  2012-03-01
  • 刊出日期:  2013-03-25

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