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PC交联脱细胞牛心包膜的力学性能、稳定性和血液相容性

马兵 翟万银 张嘉敏 孙晓宁 朱自严 张红锋 常江

马兵, 翟万银, 张嘉敏, 孙晓宁, 朱自严, 张红锋, 常江. PC交联脱细胞牛心包膜的力学性能、稳定性和血液相容性[J]. 华东师范大学学报(自然科学版), 2013, (5): 61-70, 79.
引用本文: 马兵, 翟万银, 张嘉敏, 孙晓宁, 朱自严, 张红锋, 常江. PC交联脱细胞牛心包膜的力学性能、稳定性和血液相容性[J]. 华东师范大学学报(自然科学版), 2013, (5): 61-70, 79.
MA Bing, ZHAI Wan-yin, ZHANG Jia-min, SUN Xiao-ning,  ZHU Zi-yan, ZHANG Hong-feng, CHANG Jiang. Crosslinking of decellularized bovine pericardium matrix by procyanidins: mechanical properties, stability and hemo-compatibility[J]. Journal of East China Normal University (Natural Sciences), 2013, (5): 61-70, 79.
Citation: MA Bing, ZHAI Wan-yin, ZHANG Jia-min, SUN Xiao-ning,  ZHU Zi-yan, ZHANG Hong-feng, CHANG Jiang. Crosslinking of decellularized bovine pericardium matrix by procyanidins: mechanical properties, stability and hemo-compatibility[J]. Journal of East China Normal University (Natural Sciences), 2013, (5): 61-70, 79.

PC交联脱细胞牛心包膜的力学性能、稳定性和血液相容性

详细信息
  • 中图分类号: Q33

Crosslinking of decellularized bovine pericardium matrix by procyanidins: mechanical properties, stability and hemo-compatibility

  • 摘要: 测定了原花青素(PC)交联的脱细胞牛心包膜(dbpECM)的力学性能、稳定性和血液相容性.实验结果显示,2.5 mg/mL原花青素交联能将拉伸强度从29.1 MPa提高到51.3 MPa,并保持弹性模量基本不变,而抗胶原酶降解能力与戊二醛相当;PC-dbpECM浸泡于D-Hanks溶液中,仅过量未交联原花青素在一周内释放,而交联的PC在PC-dbpECM中保持稳定.1 mg/mL PC即可基本抑制体外钙化.PC或GA交联的dbpECM都有较好的血液相容性,但PC交联明显优于GA. 2.5 mg/mL PC交联的dbpECM血小板的粘附率(7.8%)显著低于未交联组(26.1%)和GA交联组(36.6%),表明PC-dbpECM具有较好的抗血栓形成能力.结果表明PC-dbpECM具有良好的力学性能,稳定性和血液相容性,有可能成为制备人工心脏瓣膜的优良材料.
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出版历程
  • 收稿日期:  2012-07-01
  • 修回日期:  2012-10-01
  • 刊出日期:  2013-09-25

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