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YANG Li-guo, ZENG Qing-wen, ZHANG Xu-liang, CAO Xiao-hua. Long-term potentiation of prefrontal cortex in NR1 knockout mice[J]. Journal of East China Normal University (Natural Sciences), 2012, (1): 47-53.
Citation: YANG Li-guo, ZENG Qing-wen, ZHANG Xu-liang, CAO Xiao-hua. Long-term potentiation of prefrontal cortex in NR1 knockout mice[J]. Journal of East China Normal University (Natural Sciences), 2012, (1): 47-53.

Long-term potentiation of prefrontal cortex in NR1 knockout mice

  • Received Date: 2011-02-01
  • Rev Recd Date: 2011-05-01
  • Publish Date: 2012-01-25
  • This study investigated the prefrontal synaptic plasticity of forebrain-specific NR1 knockout mice by using the vitro field potential recording technique. The results from the input-output and paired pulse depression curves suggest that the basal synaptic transmission is normal in the prefrontal cortex of NR1 knockout mice. Prefrontal long-term potentiation (LTP) induced by high frequency stimulation (two trains of 100 Hz with 1 s duration and 30 s interval) was abolished in slices of NR1 knockout mice. These results indicate that NR1 is critical in the induction of long-term potentiation in prefrontal cortex.
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  • [1]
    [1]BLISS T V, COLLINGRIDGE G L. A synaptic model of memory: long-term potentiation in the hippocampus[J]. Nature, 1993, 361: 31-39.

    [2]MALENKA R C, NICOLL R A. NMDA-receptor-dependent synaptic plasticity: multiple forms and mechanisms[J]. Trends Neurosci, 1993, 16: 521-527.

    [3]BEAR M F, MALENKA R C. Synaptic plasticity: LTP and LTD[J]. Curr Opin Neurobiol, 1994(4): 389-399.

    [4]NAKANISH S. Molecular diversity of glutamate receptors and implications for brain function[J]. Science, 1992, 258: 597-603.

    [5]HOLLMANN M, HEINEMANN S. Cloned glutamate receptors[J]. Annu Rev Neurosci, 1994, 17: 31-108.

    [6]SHENG M, CUMMINGS J, ROLDAN L A, et al. Changing subunit composition of heteromeric NMDA receptors during development of rat cortex[J]. Nature, 1994, 368: 144-147.

    [7]TSIEN J Z, HUERTA P T, TONEGAWA S. The essential role of hippocampal CA1 NMDA receptor-dependent synaptic plasticity in spatial memory[J]. Cell, 1996, 87: 1327-1338.

    [8]CUI Z, WANG H, TAN Y, et al. Inducible and reversible NR1 knockout reveals crucial role of the NMDA receptor in preserving remote memories in the brain[J]. Neuron, 2004, 41: 781-793.

    [9]TANG Y P, SHIMIZU E, DUBE G R, et al. Genetic enhancement of learning and memory in mice[J]. Nature, 1999, 401: 63-69.

    [10] ROBBINS T W. From arousal to cognition: the integrative position of the prefrontal cortex[J]. Prog Brain Res, 2000, 126: 469-483.

    [11] GOTO Y, YANG C R, OTANI S. Functional and dysfunctional synaptic plasticity in prefrontal cortex: roles in psychiatric disorders[J]. Biol Psychiatry, 2010, 67: 199-207.

    [12] MATSUDA Y, MARZO A, OTANI S. The presence of background dopamine signal converts long-term synaptic depression to potentiation in rat prefrontal cortex[J]. J Neurosci, 2006, 26: 4803-4810.

    [13] ZHAO M G, TOYODA H, LEE Y S, et al. Roles of NMDA NR2B subtype receptor in prefrontal long-term potentiation and contextual fear memory[J]. Neuron, 2005, 47: 859-872.

    [14] DEBNNE D, GUERINEAU N C, GAHWILER B H, et al. Paired-pulse facilitation and depression at unitary synapses in rat hippocampus: quantal fluctuation affects subsequent release[J]. J Physiol, 1996, 491 (Pt 1): 163-176.

    [15] NICOLL R A, MALENKA R C. Contrasting properties of two forms of long-term potentiation in the hippocampus[J]. Nature, 1995, 377: 115-118.

    [16] DURAND G M, KOVALCHUK Y, KONNERTH A. Long-term potentiation and functional synapse induction in developing hippocampus[J]. Nature, 1996, 381: 71-75.

    [17] HIRSCH J C, CREPEL F. Postsynaptic calcium is necessary for the induction of LTP and LTD of monosynaptic EPSPs in prefrontal neurons: an in vitro study in the rat[J]. Synapse, 1992(10): 173-175.

    [18] WATANABE M, KODAMA T, HIKOSAKA K. Increase of extracellular dopamine in primate prefrontal cortex during a working memory task[J]. J Neurophysiol, 1997, 78: 2795-2798.

    [19] COURTNEY S M. Attention and cognitive control as emergent properties of information representation in working memory[J]. Cogn Affect Behav Neurosci, 2004(4): 501-516.[20] MATSUO K, GLAHN D C, PELUSO M A, et al. Prefrontal hyperactivation during working memory task in untreated individuals with major depressive disorder[J]. Mol Psychiatry, 2007(12): 158-166.

    [21] FUSTER J M. The prefrontal cortex-an update: time is of the essence[J]. Neuron, 2001, 30: 319-333.

    [22] WILKINS A J, SHALLICE T, MCCARTHY R. Frontal lesions and sustained attention[J]. Neuropsychologia, 1987, 25: 359-365.

    [23] ROSSI S, CAPPA S F, BABILONI C, et al. Prefrontal [correction of Prefontal] cortex in long-term memory: an “interference” approach using magnetic stimulation[J]. Nat Neurosci, 2001(4): 948-952.

    [24] HERRY C, GARCIA R. Prefrontal cortex long-term potentiation, but not long-term depression, is associated with the maintenance of extinction of learned fear in mice[J]. J Neurosci, 2002, 22: 577-583.

    [25] EGERTON A, REID L, MCKERCHAR C E, et al. Impairment in perceptual attentional set-shifting following PCP administration: a rodent model of set-shifting deficits in schizophrenia[J]. Psychopharmacology (Berl), 2005, 179: 77-84.

    [26] KOCERHA J, FAGHIHI M A, LOPEZ-TOLEDANO M A, et al. MicroRNA-219 modulates NMDA receptor-mediated neurobehavioral dysfunction[J]. Proc Natl Acad Sci USA, 2009, 106: 3507-3512.
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