Effect of forebrain NR2B overexpression on social interactions in transgenic mice

ZHANG Ning; LI Chun-xia

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ZHANG Ning, LI Chun-xia. Effect of forebrain NR2B overexpression on social interactions in transgenic mice[J]. Journal of East China Normal University (Natural Sciences), 2012, (4): 75-82.

Citation:

ZHANG Ning, LI Chun-xia. Effect of forebrain NR2B overexpression on social interactions in transgenic mice[J]. Journal of East China Normal University (Natural Sciences), 2012, (4): 75-82.

ZHANG Ning, LI Chun-xia. Effect of forebrain NR2B overexpression on social interactions in transgenic mice[J]. Journal of East China Normal University (Natural Sciences), 2012, (4): 75-82.

Citation:

ZHANG Ning, LI Chun-xia. Effect of forebrain NR2B overexpression on social interactions in transgenic mice[J]. Journal of East China Normal University (Natural Sciences), 2012, (4): 75-82.

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Effect of forebrain NR2B overexpression on social interactions in transgenic mice

ZHANG Ning¹,
LI Chun-xia^1,2

1.
Key Laboratory of Brain Functional Genomics, Ministry of Education, Shanghai Key Laboratory of Brain Functional Genomics, East China Normal University, Shanghai 200062, China;
2.
Institute of Cognitive Neuroscience, East China Normal University, Shanghai 200062, China

Received Date: 2011-04-01
Rev Recd Date: 2011-07-01
Publish Date: 2012-07-25

Abstract

Abstract

Male and female NR2B transgenic mice and their littermate controls were subjected to the social interaction test in a novel environment, sociability test and social novelty test. There was no significant difference in social interaction test in a novel environment and social novelty test among these four groups. However, compared with wild type mice, female but not male NR2B transgenic mice exhibited improvement in sociability. These results suggest that NR2B overexpression in the forebrain can improve sociability of female mice, while having no significant effect on social behaviors in male mice.
- NR2B,
- transgenic mice,
- social interaction,
- sociability,
- social novelty

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References

[1]

［1］ KUTSUWADA T, KASHIWABUCHI N, MORI H, et al. Molecular diversity of the NMDA receptor channel［J］. Nature, 1992, 358(6381): 36-41.

［2］ MONYER H, SPRENGEL R, SCHOEPFER R, et al. Heteromeric NMDA receptors: molecular and functional distinction of subtypes［J］. Science, 1992, 256(5060): 1217-1221.

［3］ MOHN A R, GAINETDINOV R R, CARON M G, et al. Mice with reduced NMDA receptor expression display behaviors related to schizophrenia［J］. Cell, 1999, 98(4): 427-436.

［4］ HALENE T B, EHRLICHMAN R S, LIANG Y, et al. Assessment of NMDA receptor NR1 subunit hypofunction in mice as a model for schizophrenia［J］. Genes, brain, and behavior, 2009, 8(7): 661-675.

［5］ PECA J, FELICIANO C, TING J T, et al. Shank3 mutant mice display autistic-like behaviours and striatal dysfunction［J］. Nature, 2011, 472(7344): 437-442.

［6］ TANG Y P, SHIMIZU E, DUBE G R, et al. Genetic enhancement of learning and memory in mice［J］. Nature, 1999, 401(6748): 63-69.

［7］ CAO X, CUI Z, FENG R, et al. Maintenance of superior learning and memory function in NR2B transgenic mice during ageing［J］. The European journal of neuroscience, 2007, 25(6): 1815-1822.

［8］ MATSUO N, TANDA K, NAKANISHI K, et al. Comprehensive behavioral phenotyping of ryanodine receptor type 3 (RyR3) knockout mice:decreased social contact duration in two social interaction tests［J］. Frontiers in behavioral neuroscience, 2009(3): 3.

［9］ MOY S S, NADLER J J, PEREZ A, et al. Sociability and preference for social novelty in five inbred strains:an approach to assess autistic-like behavior in mice［J］. Genes Brain Behav, 2004, 3(5): 287-302.

［10］ NADLER J J, MOY S S, DOLD G, et al. Automated apparatus for quantitation of social approach behaviors in mice［J］. Genes Brain Behav, 2004, 3(5): 303-314.

［11］ TANG A C, NAKAZAWA M, ROMEO R D, et al. Effects of long-term estrogen replacement on social investigation and social memory in ovariectomized C57BL/6 mice［J］. Hormones and behavior, 2005, 47(3): 350-357.

［12］ SANCHEZ-ANDRADE G, KENDRICK K M. Roles of alpha- and beta-estrogen receptors in mouse social recognition memory:effects of gender and the estrous cycle［J］. Hormones and behavior, 2011, 59(1): 114-122.

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