[1] ［1］O’KEEFE J N L. The Hippocampus as a Cognitive Map［M］. Oxford: Oxford University Press, 1978.

［2］LANGSTON R F, STEVENSON C H, WILSON C L, et al. The role of hippocampal subregions in memory for stimulus associations［J］. Behav Brain Res, 2010, 215: 275-291.

［3］TAMMINGA C A, STAN A D, WAGNER A D. The hippocampal formation in schizophrenia［J］. Am J Psychiatry, 2010, 167: 1178-1193.

［4］HSU D. The dentate gyrus as a filter or gate: a look back and a look ahead［J］. Prog Brain Res, 2007, 163: 601-613.

［5］SAHAY A, DREW M R, HEN R. Dentate gyrus neurogenesis and depression［J］. Prog Brain Res, 2007, 163: 697-722.

［6］CAO X, WANG H, MEI B， et al. Inducible and selective erasure of memories in the mouse brain via chemical-genetic manipulation［J］. Neuron, 2008, 60: 353-366.

［7］MAYFORD M, WANG J, KANDEL E R， et al. CaMKII regulates the frequency-response function of hippocampal synapses for the production of both LTD and LTP［J］. Cell, 1995, 81: 891-904.

［8］SILVA A J, PAYLOR R, WEHNER J M，et al. Impaired spatial learning in alpha-calcium-calmodulin kinase II mutant mice［J］. Science, 1992, 257: 206-211.

［9］BENNETT M K, ERONDU N E, KENNEDY M B. Purification and characterization of a calmodulin-dependent protein kinase that is highly concentrated in brain［J］. J Biol Chem, 1983, 258: 12735-12744.

［10］ ERONDU N E, KENNEDY M B. Regional distribution of type II Ca2+/calmodulin-dependent protein kinase in rat brain［J］. J Neurosci, 1985(5): 3270-3277.

［11］ HAYASHI Y, SHI S H, ESTEBAN J A， et al. Driving AMPA receptors into synapses by LTP and CaMKII: requirement for GluR1 and PDZ domain interaction［J］. Science, 2000, 287: 2262-2267.

［12］ PONCER J C, ESTEBAN J A, MALINOW R. Multiple mechanisms for the potentiation of AMPA receptor-mediated transmission by alpha-Ca2+/calmodulin-dependent protein kinase II［J］. J Neurosci, 2002, 22: 4406-4411.

［13］ CHO MH, CAO X, WANG D〖WTBX〗，〖WTBZ〗et al. Dentate gyrus-specific manipulation of beta-Ca2+/calmodulin-dependent kinase II disrupts memory consolidation［J］. Proc Natl Acad Sci U S A, 2007, 104: 16317-16322.

［14］ NICHOLLS R E, ALARCON J M, MALLERET G〖WTBX〗，〖WTBZ〗et al. Transgenic mice lacking NMDAR-dependent LTD exhibit deficits in behavioral flexibility［J］. Neuron, 2008, 58: 104-117.

［15］ TSIEN J Z, HUERTA P T, TONEGAWA S. The essential role of hippocampal CA1 NMDA receptor-dependent synaptic plasticity in spatial memory［J］. Cell, 1996, 87: 1327-1338.

［16］ SCHNABEL R, PALMER M J, KILPATRICK I C， et al. A CaMKII inhibitor, KN-62, facilitates DHPG-induced LTD in the CA1 region of the hippocampus［J］. Neuropharmacology, 1999, 38: 605-608.

［17］ KIRKWOOD A, SILVA A, BEAR M F. Age-dependent decrease of synaptic plasticity in the neocortex of alphaCaMKII mutant mice［J］. Proc Natl Acad Sci U S A, 1997, 94: 3380-3383.

［18］ LAI Y, NAIRN A C, GREENGARD P. Autophosphorylation reversibly regulates the Ca2+/calmodulin-dependence of Ca2+/calmodulin-dependent protein kinase II［J］. Proc Natl Acad Sci USA, 1986, 83: 4253-4257.

［19］ BROCKE L, CHIANG L W, WAGNER P D， et al. Functional implications of the subunit composition of neuronal CaM kinase II［J］. J Biol Chem, 1999, 274: 22713-22722.

［20］ SHEN K, MEYER T. Dynamic control of CaMKII translocation and localization in hippocampal neurons by NMDA receptor stimulation［J］. Science, 1999, 284: 162-166.

［21］ SHEN K, TERUEL M N, CONNOR J H， et al. Molecular memory by reversible translocation of calcium/calmodulin-dependent protein kinase II［J］. Nat Neurosci, 2000(3): 881-886.

［22］ THIAGARAJAN T C, PIEDRAS-RENTERIA E S, TSIEN R W. Alpha- and betaCaMKII. Inverse regulation by neuronal activity and opposing effects on synaptic strength［J］. Neuron, 2002, 36: 1103-1114.

［23］ LEE H K, BARBAROSIE M, KAMEYAMA K， et al. Regulation of distinct AMPA receptor phosphorylation sites during bidirectional synaptic plasticity［J］. Nature, 2000, 405: 955-959.

［24］ DEBANNE D, GUERINEAU N C, GAHWILER B H， et al. Paired-pulse facilitation and depression at unitary synapses in rat hippocampus: quantal fluctuation affects subsequent release［J］. J Physiol, 1996, 491 ( Pt 1): 163-176.

［25］ ZUCKER R S, REGEHR W G. Short-term synaptic plasticity［J］. Annu Rev Physiol, 2002, 64: 355-405.

［26］ MASSEY P V, BASHIR Z I. Long-term depression: multiple forms and implications for brain function［J］. Trends Neurosci, 2007, 30: 176-184.

［27］ KEMP A, MANAHAN-VAUGHAN D. Hippocampal long-term depression: master or minion in declarative memory processes?［J］. Trends Neurosci, 2007, 30: 111-118.

［28］ ZENG H, CHATTARJI S, BARBAROSIE M， et al. Forebrain-specific calcineurin knockout selectively impairs bidirectional synaptic plasticity and working/episodic-like memory［J］. Cell, 2001, 107: 617-629.