[1] ［1］BUSH J A, CHEUNG K J JR, LI G. Curcumin induces apoptosis in human melanoma cells through a FAS receptor/caspase-8 pathway independent of p53［J］. Exp Cell Res, 2001, 271(2): 305-314.

［2］PAN M H, CHANG W L, LIN-SHIAU S Y, et al. Induction of apoptosis by garcinol and curcumin through cytochrome c release and activation of caspases in human leukemia HL-60 cells［J］. J Agric Food Chem, 2001, 49(3): 1464-1474.

［3］肖红艳,温玉库.姜黄素抗癌作用及机制研究进展［J］.社区医学杂志, 2006, 12(4): 40-42.

［4］陆鹏,童强松,姜凤超,等. 姜黄素前体药物的合成及其体外抗肿瘤活性研究［J］.中国药理学通报,2006, 22(3): 321-324.

［5］韦星船,杜志云,涂增清,等. 姜黄素衍生物与类似物的构效关系研究进展［J］.化学研究与应用, 2010, 22(5): 527-538.

［6］张磊，李杰，陈国良.姜黄素衍生物生物活性的研究进展［J］.沈阳药科大学学报,2008, 25(4): 331-336.

［7］DENG X K, YIN W, LI W D, et al. The anti-tumor effects of alkaloids from the seeds of Strychnos nux-vomica on HepG2 cells and its possible mechanism［J］. J Ethnopharmacol, 2006, 106(2): 179-186.

［8］GAO W, LAM W, ZHONG S, et al. Novel mode of action of tylophorine analogs as antitumor compounds［J］. Cancer Res, 2004, 64(2): 678-688.

［9］ZhANG H N, YU C X, ZhANG P J, et al. Curcumin downregulates homeobox gene NKX3.1 in prostate cancer cell LNCaP［J］. Acta Pharmacol Sin, 2007, 28(3): 423-430.

［10］ KOIKE K, TAKAK A, TATSUKAWA M, et al. Combination of 5-FU and IFNalpha enhances IFN signaling pathway and caspase-8 activity, resulting in marked apoptosis in hepatoma cell lines［J］. Int J Oncol, 2006, 29(5): 1253-1261.

［11］ KHAFIF A, SCHANTZ S P, CHOU T C, et al. Quantitation of chemopreventive synergism between (-)-epigallocatechin-3-gallate and curcumin in normal, premalignant and malignant human oral epithelial cells［J］. Carcinogenesis, 1998, 19(3): 419-424.

［12］ AOKI H, TAKADA Y, KONDO S, et al. Evidence that curcumin suppresses the growth of malignant gliomas in vitro and in vivo through induction of autophagy: role of Akt and extracellular signal-regulated kinase signaling pathways［J］. Mol Pharmacol, 2007, 72(1): 29-39.

［13］ LEV-ARI S, STARR A, VEXLER A, et al. Inhibition of pancreatic and lung adenocarcinoma cell survival by curcumin is associated with increased apoptosis, down-regulation of COX-2 and EGFR and inhibition of Erk1/2 activity［J］. Anticancer Res, 2006, 26(6B): 4423-4430.

［14］ PARK C, KIM G Y, KIM G D, et al. Induction of G2/M arrest and inhibition of cyclooxygenase-2 activity by curcumin in human bladder cancer T24 cells［J］. Oncol Rep, 2006, 15(5): 1225-1231.

［15］ ROBERTSON G S, CROCKER S J, NICHOLSON D W, et al. Neuroprotection by the inhibition of apoptosis［J］. Brain Pathol, 2000, 10(2): 283-292.

［16］ PAL S, CHOUDHURI T, CHATTOPADHYAY S, et al. Mechanisms of curcumin-induced apoptosis of Ehrlich's ascites carcinoma cells［J］. Biochem Biophys Res Commun, 2001, 288(3): 658-665.

［17］ SHANKAR S, CHEN Q, SARVA K, et al. Curcumin enhances the apoptosis-inducing potential of TRAIL in 〖JP2〗prostate cancer cells: molecular mechanisms of apoptosis, migration and angiogenesis［J］. J Mol Signal, 2007(2):10.〖JP〗

［18］ VOLATE S R, DAVENPORT D M, MUGA S J, et al. Modulation of aberrant crypt foci and apoptosis by dietary 〖JP2〗herbal supplements (quercetin, curcumin, silymarin, ginseng and rutin)［J］. Carcinogenesis, 2005, 26(8): 1450-1456.〖JP〗

［19］ SU C C, LIN J G, LI T M, et al. Curcumin-induced apoptosis of human colon cancer colo 205 cells through the production of ROS, Ca2+ and the activation of caspase-3［J］. Anticancer Res, 2006, 26(6B): 4379-4389.

［20］ TAN T W, TSAI H R, LU H F, et al. Curcumin-induced cell cycle arrest and apoptosis in human acute 〖JP2〗promyelocytic leukemia HL-60 cells via MMP changes and caspase-3 activation［J］. Anticancer Res, 2006, 26(6B): 4361-4371.〖JP〗

［21］ ASHKENAZI A. Targeting death and decoy receptors of the tumour-necrosis factor superfamily［J］. Nat Rev Cancer, 2002, 2(6): 420-430.

［22］ FULAD S, DEBATIN K M. Extrinsic versus intrinsic apoptosis pathways in anticancer chemotherapy［J］. Oncogene, 2006, 25(34): 4798-4811.

［23］ WANG J, CHUN H J, WONG W, et al. Caspase-10 is an initiator caspase in death receptor signaling［J］. Proc Natl Acad Sci U S A, 2001, 98(24): 13884-13888.

［24］ MORAGODA L, JASZEWSKI R, MAJUMDAR A P. Curcumin induced modulation of cell cycle and apoptosis in gastric and colon cancer cells［J］. Anticancer Res, 2001, 21(2A): 873-878.

［25］ LOGAN-SMITH M J, EAST J M, LEE A G. Evidence for a global inhibitor-induced conformation change on the Ca(2+)-ATPase of sarcoplasmic reticulum from paired inhibitor studies［J］. Biochemistry, 2002, 41(8): 2869-2875.

［26］ LOGAN-SMITH M J, LOCKYER P J, EAST J M, et al. Curcumin, a molecule that inhibits the Ca2+-ATPase of sarcoplasmic reticulum but increases the rate of accumulation of Ca2+［J］. J Biol Chem, 2001, 276(50): 46905-46911.

［27］ PAE H O, JEONG S O, JEONG G S, et al. Curcumin induces pro-apoptotic endoplasmic reticulum stress in human leukemia HL-60 cells［J］. Biochem Biophys Res Commun, 2007, 353(4): 1040-1045.

［28］ BAKHSHI J, WEINSTEIN L, POKSAY K S, et al. Coupling endoplasmic reticulum stress to the cell death program in mouse melanoma cells: effect of curcumin［J］. Apoptosis, 2008, 13(7): 904-914.

［29］ MARIN Y E, WALL B A, WANG S, et al. Curcumin downregulates the constitutive activity of NF-kappaB and induces apoptosis in novel mouse melanoma cells［J］. Melanoma Res, 2007, 17(5): 274-283.

［30］ AGGARWAL S, TAKADA Y, SINGH S, et al. Inhibition of growth and survival of human head and neck squamous cell carcinoma cells by curcumin via modulation of nuclear factor-kappaB signaling［J］. Int J Cancer, 2004, 111(5): 679-692.

［31］ LIU C A, WAMG M J, CHI C W, et al. Rho/Rhotekin-mediated NF-kappaB activation confers resistance to apoptosis［J］. Oncogene, 2004, 23(54): 8731-8742.

［32］ TOMITA M, KAWAKAMI H, UCHIHARA J N, et al. Curcumin (diferuloylmethane) inhibits constitutive active NF-kappaB, leading to suppression of cell growth of human T-cell leukemia virus type I-infected T-cell lines and primary adult T-cell leukemia cells［J］. Int J Cancer, 2006, 118(3): 765-772.

［33］ HUSSAIN A R, Al-RASHEED M, MANOGARAN P S, et al. Curcumin induces apoptosis via inhibition of PI3'-kinase/AKT pathway in acute T cell leukemias［J］. Apoptosis, 2006, 11(2): 245-254.

［34］ GURURAJAN M, DASU T, SHAHIDAIN S, et al. Spleen tyrosine kinase (Syk), a novel target of curcumin, is required for B lymphoma growth［J］. J Immunol, 2007, 178(1): 111-121.

［35］ BEEVERS C S, LI F, LIU L, et al. Curcumin inhibits the mammalian target of rapamycin-mediated signaling pathways in cancer cells［J］. Int J Cancer, 2006, 119(4): 757-764.

［36］ SQUIRES M S, HUDSON E A, HOWELLS L, et al. Relevance of mitogen activated protein kinase (MAPK) and phosphotidylinositol-3-kinase/protein kinase B (PI3K/PKB) pathways to induction of apoptosis by curcumin in breast cells［J］. Biochem Pharmacol, 2003, 65(3): 361-376.

［37］ HAY N, SONENBERG N. Upstream and downstream of mTOR［J］. Genes Dev, 2004, 18(16): 1926-1945.

［38］ DEAN M, FOJO T, BATES S. Tumor stem cells and drug resistance［J］. Nat Rev Cancer, 2005, 5(4): 275-284.