Role of central neuromedin U in regulating feeding behavior ispartially mediated by the melanocortin pathway （Chinese）
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摘要: 研究中枢神经介素U（NMU）受体2（NMU2R）与黑皮质激素（MC）受体途径（MCR3/4）在调节摄食行为和能量平衡方面的相互作用关系.对禁食或不禁食大鼠脑室注射NMU2R内源性配体NMU和MCR3/4信号途径高亲和力拮抗剂SHU9119，通过测定不同时间点大鼠摄食量和体重变化，探讨中枢NMU2R和黑皮质素受体途径在调节动物摄食行为上的作用及其相互关系.脑室注射NMU对大鼠食欲有显著抑制作用；在同时注射NMU和SHU9119的情况下，NMU2R对大鼠的这种食欲抑制作用会部分受到MCR3/4信号途径变化的影响；同样，对SHU9119前处理大鼠脑内注射NMU，NMU2R抑制食欲的作用也会明显降低，其在摄食方面的作用被部分抑制.结果提示，NMU能够有效的调节摄食行为，而且这种在摄食行为上的调控作用可能部分受MC受体途径介导.Abstract: This paper investigated the associations between central neuromedin U (NMU) receptor 2 (NMU2R) and melanocortin (MC) receptor pathway (MCR3/4) in regulation of food intake and energy homeostasis. NMU, the endogenous ligand of NMU2R in hypothalamus, and SHU9119, a highaffinity antagonist of MCR3/4 pathway, were intracerebraventricularly (ICV) administrated to the fasting and nonfasting rats. The effects of NMU2R on feeding behavior and body weights and their relationships with the role of MCR3/4 signaling were evaluated in the absence or presence of SHU9119 in the rat. The results showed that ICV administration of NMU significantly decreased the food intake as observed at different time points. The anorexigenic effect of NMU was partially inhibited by ICV coadministration of NMU and SHU9119. Furthermore, ICV injection of NMU showed a similar pattern of reduced anorexigenic effect of NMU in SHU9119pretreated rats. These results suggest that functional agonism of NMU2R by NMU in the central nervous system can effectively regulate feeding behavior and energy homeostasis. The central modulation of NMU2R on feeding behavior is associated, at least in part, with melanocortin receptor pathway.
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