IRF7表达与系统性红斑狼疮的相关性

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IRF7 expression and its association with systemic lupus erythematosus

1.
Department of Life Science, East China Normal University, Shanghai 200062, China;
2.
Molecular Rheumatology Lab, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Shanghai 200025, China;
3.
Department of Rheumatology, Renji Hospital Affiliated to Medical College ofShanghai Jiaotong University, Shanghai 200001, China

摘要: 探讨了干扰素调节因子7(IRF7)的表达与中国汉族人群系统性红斑狼疮（SLE）的相关性.运用实时荧光定量聚合酶链式反应的方法分别测定疾病患者与正常对照组外周血IRF7 mRNA的表达水平，并与血清中干扰素水平、干扰素积分以及SLEDAI积分作相关性分析.结果发现，患者外周血IRF7 mRNA的表达水平较正常对照组的明显增高，且其与血清中干扰素水平、干扰素积分以及SLEDAI积分均呈正相关.由此可知，IRF7表达的增高可能促使干扰素通路异常激活，从而导致系统性红斑狼疮的发生.
- 系统性红斑狼疮 /
- 干扰素调节因子7 /
- 表达
Abstract: To explore the relationship between the expressions of interferon regulatory factor 7 (IRF7) and the pathogenesis of SLE in Chinese Han cohort, the IRF7 mRNA expression levels in peripheral blood of patients and normal individuals were tested by using realtime quantitative PCR technique, and then were compared with the IFN level in serum, IFN score and SLEDAI score. It is demonstrated that the expression level of IRF7 mRNA in SLE patients is significantly increased, and is positively correlated with the IFN level in serum, IFN score and SLEDAI score. So it is concluded that the increase of IRF7 expression may excessively activate the interferon pathway and lead to SLE.
- systemic lupus erythematosusinterferon regulation factor 7expression /