中国综合性科技类核心期刊(北大核心)

中国科学引文数据库来源期刊(CSCD)

美国《化学文摘》(CA)收录

美国《数学评论》(MR)收录

俄罗斯《文摘杂志》收录

留言板

尊敬的读者、作者、审稿人, 关于本刊的投稿、审稿、编辑和出版的任何问题, 您可以本页添加留言。我们将尽快给您答复。谢谢您的支持!

姓名
邮箱
手机号码
标题
留言内容
验证码

黑色素的合成与美白产品的研究进展

叶希韵 朱萍亚

叶希韵, 朱萍亚. 黑色素的合成与美白产品的研究进展[J]. 华东师范大学学报(自然科学版), 2016, (2): 1-8. doi: 10.3969/j.issn.1000-5641.2016.02.001
引用本文: 叶希韵, 朱萍亚. 黑色素的合成与美白产品的研究进展[J]. 华东师范大学学报(自然科学版), 2016, (2): 1-8. doi: 10.3969/j.issn.1000-5641.2016.02.001
YE Xi-yun, ZHU Ping-ya. A review of the studies on melanin synthesis and whitening products[J]. Journal of East China Normal University (Natural Sciences), 2016, (2): 1-8. doi: 10.3969/j.issn.1000-5641.2016.02.001
Citation: YE Xi-yun, ZHU Ping-ya. A review of the studies on melanin synthesis and whitening products[J]. Journal of East China Normal University (Natural Sciences), 2016, (2): 1-8. doi: 10.3969/j.issn.1000-5641.2016.02.001

黑色素的合成与美白产品的研究进展

doi: 10.3969/j.issn.1000-5641.2016.02.001
基金项目: 

上海市科委基础重点项目(13JC1405102);国家自然科学基金(81272226)

详细信息
    通讯作者:

    叶希韵,女,教授,研究方向为细胞的损伤与修复.

  • 中图分类号: Q26

A review of the studies on melanin synthesis and whitening products

  • 摘要: 随着环境污染对大气臭氧层的不断破坏,越来越多的紫外线照射到地球表面,加重了人类皮肤色素沉积异常. 本文将介绍黑色素的合成过程,并综述黑色素合成过程中的关键限速酶酪氨酸酶(TYR)的调控方式和相关信号通路的最新研究进展,还介绍了影响黑色素合成的重要因素,为黑色素抑制剂的研发提供理论依据. 此外,本文还综述了目前市场上常见的几类美白产品及其特点,旨在让人们重视肌肤色素沉着问题,并关注对皮肤黑色素产生进行科学护理. 
  • [1] [1]ORTONNE J P. Photoprotective properties of skin melanin[J]. Brit J Dermatol, 2002,146(61): 710.

    [2]KOLLIAS N, BAQER A H. Absorption mechanisms of human melanin in the visible 400720nm[J]. J Dermatol Sci, 1987, 89: 384388.

    [3]BRANZANICHITA N, NEGROIU G, PETRESCU A J, et al. Mutations at critical Nglycosylation sites reduce tyrosinase activity by altering folding and quality control[J]. J Biol Chem, 2000,275(11): 81698175.

    [4]SCHEPSKY A, BRUSER K, GUNNARSSON G J, et al. The microphthalmiaassociated transcription factor Mitf interacts with βcatenin to determine target gene expression[J]. Mol Cell Biol, 2006, 26(23): 89148927.

    [5]BU J, MA P C, ZHOU W Q, et al. Inhibition of MITF and tyrosinase by paeonolstimulated JNK/SAPK to reduction of phosphorylated CREB[J]. Am J Chinese Med, 2008,36(2): 245263.

    [6]BEAULIEU J M, GAINETDINOV R R, CARON M G. Akt/GSK3 signaling in the action of psychotropic drugs[J]. Annu Rev Pharmacol Toxicol, 2009, 49: 327347.

    [7]MIZUTANI Y, HAYASHI N, KAWASHIMA M, et al. A single UVB exposure increases the expression of functional KIT in human melanocytes by upregulating MITF expression through the phosphorylation of p38/CREB[J]. Arch Dermatol Res, 2010,302(4): 283294.

    [8]YE Y, WANG H, CHU J H, et al. Activation of p38 MAPK pathway contributes to the melanogenic property of apigenin in B16 cells[J]. Exp Dermatol, 2011,20(9): 755757.

    [9] BU J, MA P C, CHEN Z Q, et al. Inhibition of MITF and tyrosinase by paeonolstimulated JNK/SAPK to reduction of phosphorylated CREB[J]. Am J Chinese Med, 2008,36(2): 245263.

    [10]XU W, GONG L, HADDAD M M, et al. Regulation of microphthalmiaassociated transcription factor MITF protein levels by association with the ubiquitinconjugating enzyme hUBC9[J]. Exp Cell Res, 2000,255(2): 135143.

    [11]ANDO H, ICHIHASHI M, HEARING V J. Role of the Ubiquitin proteasome system in regulating skin pigmentation[J]. Int J Mol Sci, 2009; 10(10): 44284434.

    [12]PARK H Y, PEREZ J M, LAURSEN R, et al. Protein kinase Cb activates tyrosinase by phosphorylating serine residues in its cytoplasmic domain[J]. J Biol Chem, 1999,274(23): 1647016478.

    [13]BELLEI B, MARESCA V, FLORI E, et al. P38 regulates pigmentation via proteasomal degradation of tyrosinase[J]. J Biol Chem, 2010,285(10): 72887299.

    [14]JEONG H S, CHOI H R, YUN H Y, et al. Ceramide PC102 inhibits melanin synthesis via proteasomal degradation of microphthalmiaassociated transcription factor and tyrosinase[J]. Mole Cell Bioch, 2013, 375(1/2): 8187.

    [15]PARK S H, KIM D S, LEE H K, et al. Longterm suppression of tyrosinase by terrein via tyrosinase degradation and its decreased expression[J]. Exp Dermatol, 2009, 18(6): 562566.

    [16]MARIN M B, GHENEA S, SPIRIDON L N, et al. Tyrosinase degradation is prevented when EDEM1 lacks the intrinsically disordered region[J]. PLoS ONE, 2012,7(8): e42998.

    [17]ROUTABOUL C, DENIS A, VINCHE A. Immediate pigment darkening: Description, kinetic and biological function[J]. Eur J Dermatol, 1999,9(2): 9599.

    [18]WICKS N L, CHAN J W, NAJERA J A, et al. UVA phototransduction drives early melanin synthesis in human melanocytes[J]. Curr Biol, 2011,21(22): 19061911.

    [19]SUSCHEK C V, PAUNEL A, KOLBBACHOFEN V. Nonenzymatic nitric oxide formation during UVA irradiation of human skin: Experimental setups and ways to measure[J]. Methods Enzymol, 2005,396: 568578.

    [20]CHAKRABORTY A K, FUNASAKA Y, SLOMINSKI A, et al. Production and release of proopiomelanocortin (POMC) derived peptides by human melanocytes and keratinocytes in culture: Regulation by ultraviolet B[J]. Biochim Biophys Acta, 1996,1313(2): 130138.

    [21]ELLER M S, OSTROM K, GILCHREST B A. DNA damage enhances melanogenesis[J]. Proc Nat Acad Sci USA, 1996,93(3): 10871092.

    [22]KUWAMOTO K, MIYAUCHIHASHIMOTO H, TANAKA K, et al. Possible involvement of enhanced prostaglandin E2 production in the photosensitivity in xeroderma pigmentosum group A model mice[J]. J Invest Dermatol, 2000,114(2): 241246.

    [23]BROBERG A, AUGUSTSSON A. Atopic dermatitis and melanocytic naevi[J]. Br J Dermatol, 2000,142(2): 306309.

    [24]BEHM B, BABILAS P, LANDTHALER M, et al. Cytokines, chemokines and growth factors in wound healing[J]. J Eur Acad Dermatol Venereol, 2012,26(7): 812820.

    [25]CHOI H, CHOI H, JIN S H, et al. IL4 inhibits the melanogenesis of normal human melanocytes through the JAK2STAT6 signaling pathway[J]. J Invest Dermatol, 2013,133(2): 528536.

    [26]JIAN D, JIANG D, SU J, et al. Diethylstilbestrol enhances melanogenesis via cAMPPKAmediating upregulation of tyrosinase and MITF in mouse B16 melanoma cells[J]. Steroids, 2011,76(12): 12971304.

    [27]STARNER R J, MCCLELLAND L, ABDELMALEK Z, et al. PGE2 is a UVRinducible autocrine factor for human melanocytes that stimulates tyrosinase activation[J]. Exp Dermatol, 2010,19(7): 682684.

    [28]IM S, LEE E S, KIM W, et al. Donor specific response of estrogen and progesterone on cultured human melanocytes[J]. J Korean Med Sci, 2002,17(1): 5864.

    [29]HOSHINO T, MATSUDA M, YAMASHITA Y, et al. Suppression of melanin production by expression of HSP70[J]. J Biol Chem, 2010,285(17): 1325413263.

    [30]HE Y D, LIU Y T, LIN Q X, et al. Polydatin suppresses ultraviolet Binduced cycooxygenase2 expression in vitro and in vivo via reduced production of reactive oxygen species[J]. British Journal of Dermatology, 2012,167: 941944

    [31]ZHAI Y M, DANG Y Y, GAO W K, et al. P38 and JNK signal pathways are involved in the regulation of phlorizin against UVBinduced skin damage[J]. Experimental Dermatology, 2015,24(4):275279

    [32]GUPTA R S, GUPTA E S, DHAKAL B K, et al. Vitamin C and vitamin E protect the rat testes from cadmiuminduced reactive oxygen species[J]. Mole Cell, 2004,17(1): 132139.

    [33]JOSHI R, GANGABHAGIRATHI R, VENU S, et al. Antioxidant activity and free radical scavenging reactions of gentisic acid: Invitro and pulse radiolysis studies[J]. Free Radical Res, 2012,46(1): 1120.

    [34]VILLARAMA C D, MAIBACH H I. Glutathione as a depigmenting agent: An overview[J]. Int J Cosmet Sci, 2005, 27(3): 147153.

    [35]CHANG L W, JUANG L J, WANG B S, et al. Antioxidant and antityrosinase activity of mulberry (Morus alba L.) twigs and root bark[J]. Food Chem Toxicol, 2011,49(4): 785790.

    [36]DIWAKAR G, RANA J, SAITO L, et al. Inhibitory effect of a novel combination of Salvia hispanica (chia) seed and Punica granatum (pomegranate) fruit extracts on melanin production[J]. Fitoterapia, 2014,97: 164171.

    [37]ZHU P Y, YIN W H, WANG M R, et al. Andrographolide suppresses melanin synthesis through Akt/GSK3β/βcatenin signal pathway[J]. Journal of Dermatological Science, 2015, 79: 7483

    [38]LEE H, KIM E H, CHOI H R, et al. Dipeptides inhibit melanin synthesis in MelAb cells through downregulation of tyrosinase[J]. Korean J Physiol Pharmacol, 2012,16(4): 287291.

    [39]KOLBE L, MANN T, GERWAT W, et al. 4Nbutylresorcinol, a highly effective tyrosinase inhibitor for the topical treatment of hyperpigmentation[J]. Journal of the European Academy of Dermatology and Venereology, 2013, 27(s1): 1923.
  • 加载中
计量
  • 文章访问数:  700
  • HTML全文浏览量:  63
  • PDF下载量:  920
  • 被引次数: 0
出版历程
  • 收稿日期:  2015-07-01
  • 刊出日期:  2016-03-25

目录

    /

    返回文章
    返回