Effects of Procyanidins on Preventing Mitochondria Damage in Rat Liver Induced by •OH
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摘要: 采用分光光度法和荧光偏振法，检测了原花青素对•OH引起的鼠肝线粒体损伤的保护作用.结果表明，原花青素能有效增加受损伤的线粒体的膜脂流动性，明显减少受损伤的线粒体肿胀及脂质过氧化物的形成,从而维护线粒体结构和功能的完整性.以上结果为原花青素的进一步开发提供了新的资料.Abstract: Oxidative damage of the mitochondria plays an important role in generating and developing process of many diseases.Hydroxyl radical (#8226;OH) has been considered an important factor inducing mitochondria damage.Therefore,it has important significance to study and exploit medicines protecting mitochondria damage caused by #8226;OH.We measured effects of procyanidins preventing mitochondria damage induced by#8226;OH using spectrophotometry and fluorescent polarimetry.The results showed that procyanidins increased effectively membrane lipids fluidity of damaged mitochondria,decreased significantly the mitochondria swelling and lipid peroxidation product formation.As a result,procyanidins can maintain the integrity of structure and function of mitochondria.Above results can provide new data for further exploitation of procyanidins.
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