Study of synthesis of 3-(4-phenyl-1,3-dithiolan-2-ylidene)pentane-2,4-dione and its condensation reaction with arylaldehydes(Chinese)
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摘要: 以碳酸钾为碱,N,以N-二甲基甲酰胺为溶剂,乙酰丙酮与二硫化碳及1,2-二溴苯乙烷反应,以中等产率(47%)合成了3-(4-苯基-1,3-二硫戊环-2-亚甲基)-2,4-戊二酮2.碱性条件下,化合物2比较稳定,通过对碱的选择和芳醛量的控制,化合物2与芳醛缩合可分别以较高的产率合成单面和双面缩合产物1d和1e.
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关键词:
- 3-(4-苯基-1 /
- 3-二硫戊环-2-亚甲基)-2 /
- 4-戊二酮 /
- 芳醛 /
- 缩合反应
Abstract: 3-(4-Phenyl-1,3-dithiolan-2-ylidene)pentane-2,4-dione (2) was prepared in moderate(47%) yield by the reaction of acetylacetone with carbon disulfide and 1-(1,2-dibromoethyl)benzene using potassium carbonate as base.Under the optimized conditions, the condensation of compound 2 with arylaldehydes led to the corresponding products α-acetyl-α′cinnamoyl ketene dithioacetals 1d and α,α′-dicinnamoyl ketene dithioacetals 1e, respectively, in high to excellent yields.
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