-
摘要: 利用前额叶脑区过量表达β钙离子/钙调素依赖的蛋白激酶II（βCaMKII）的蛋白修饰转基因小鼠，研究βCaMKII对小鼠工作记忆的影响.Western Blot结果显示，转基因小鼠前额叶脑区的βCaMKII过量表达.在修饰的水迷宫实验中，与对照组相比，转基因小鼠的逃避潜伏期没有发生明显变化.此外，在T迷宫实验中，转基因小鼠的正确率与对照组的正确率也基本相同.由此推测，βCaMKII的过量表达对于前额叶皮层依赖的工作记忆没有明显的影响.
-
关键词:
- 工作记忆 /
- β钙离子/钙调素依赖的蛋白激酶Ⅱ /
- 前额叶
Abstract: This experiment was designed to investigate the effect of the βCa2+/calmodulin dependent protein kinases II(βCaMKII) on the working memory in mice. The result of Western Blot showed that βCaMKII was overexpressed in the prefrontal cortex in transgenic mice. There was no significance in escape latency between transgenic mice and controls in Morris water maze. In addition, the correct of transgenic mice in T maze was also similar to that of controls. These results suppose that overexpression of the βCaMKII has no significant effect on the prefrontal cortex dependent working memory in mice. -
点击查看大图
计量
- 文章访问数: 2353
- HTML全文浏览量: 12
- PDF下载量: 1459
- 被引次数: 0
下载: