Effects of PFOS exposure on lifespan in C. elegans and their relations with IIS genes

LI Dan; WU Jing-xuan; LI Jia; HE De-fu; 

doi:10.3969/j.issn.1000-5641.2015.02.013

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May 2015

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LI Dan, WU Jing-xuan, LI Jia, HE De-fu, . Effects of PFOS exposure on lifespan in C. elegans and their relations with IIS genes[J]. Journal of East China Normal University (Natural Sciences), 2015, (2): 106-112. doi: 10.3969/j.issn.1000-5641.2015.02.013

Citation:

LI Dan, WU Jing-xuan, LI Jia, HE De-fu, . Effects of PFOS exposure on lifespan in C. elegans and their relations with IIS genes[J]. Journal of East China Normal University (Natural Sciences), 2015, (2): 106-112. doi: 10.3969/j.issn.1000-5641.2015.02.013

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Effects of PFOS exposure on lifespan in C. elegans and their relations with IIS genes

doi: 10.3969/j.issn.1000-5641.2015.02.013

LI Dan^1,2,
WU Jing-xuan^1,2,
LI Jia^1,2,
HE De-fu^{1,2
,
,},


1.
School of Ecological and Environmental Sciences, East China Normal University, Shanghai200241, China;
2.
Shanghai Key Lab for Urban Ecological Processes and Eco Restoration, East China Normal University, Shanghai200241, China

Received Date: 2014-09-12
Publish Date: 2015-03-25

Abstract

Abstract

Using a model of C.elegans, this study aims to investigate the effect of PFOS on the lifespan and its mechanisms. Results showed that 0.2~200 mol/L PFOS shortened the lifespan of wild type wormsin a concentrationdependent manner after 50 h exposure.In four transgenic strains, mutation of daf-16, daf-2 and age-1 which are related to Insulin/IGFl.1pathway(IIS), could affect the lifespans of nematodes. We further observed lifespan change rates of the four transgene C.elegansafter exposed to PFOS.Results showed that mutation of daf-16 or daf-2 did not alter PFOS induced effects of shortening lifespan in CF1139 and CF1580 strain.However, knockout of daf-16b or mutation of age-1blocked PFOS induced effects of shortening lifespan in CF1295 and TJ1052 strain. Our results suggested that PFOS could accelerate aging and shorten the lifespan of nematodes. PFOSinduced effects are closely relative with IIS signaling pathways, in which daf-16b and age-1 play important roles.
- PFOSC.elegans lifespan IIS signaling pathway daf-16b age-1,

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References(1)

References

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