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Issue 4
Jul.  2019
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YANG Jun-xian, XIE Bao-ying. A class of delayed HIV-1 infection models with latently infected cells[J]. Journal of East China Normal University (Natural Sciences), 2019, (4): 19-32. doi: 10.3969/j.issn.1000-5641.2019.04.003
Citation: YANG Jun-xian, XIE Bao-ying. A class of delayed HIV-1 infection models with latently infected cells[J]. Journal of East China Normal University (Natural Sciences), 2019, (4): 19-32. doi: 10.3969/j.issn.1000-5641.2019.04.003

A class of delayed HIV-1 infection models with latently infected cells

doi: 10.3969/j.issn.1000-5641.2019.04.003
  • Received Date: 2018-05-16
  • Publish Date: 2019-07-25
  • A class of delayed HIV-1 infection models with latently infected cells was proposed. The basic reproductive number $ R_0 $ was defined, and the existence conditions of disease-free equilibrium $ P_0 (x_0 , \, 0, \, 0, \, 0) $ and chronic-infection equilibrium $ P^\ast (x^\ast , \, \omega ^\ast , \, y^\ast , \, v^\ast ) $ were given. First, the local asymptotic stability of infection-free equilibrium and chronic-infection equilibrium was obtained by the linearization method. Further, by constructing the corresponding Lyapunov functions and using LaSalle's invariant principle, it was proved that when the basic reproductive number $ R_0 $ was less than or equal to unity, the infection-free equilibrium $ P_0 (x_0 , \, 0, \, 0, \, 0) $ was globally asymptotically stable; moreover, when the basic reproductive number $ R_0 $ was greater than unity, the chronic-infective equilibrium $ P^\ast (x^\ast , \, \omega ^\ast , \, y^\ast , \, v^\ast ) $ was globally asymptotically stable, but the infection-free equilibrium $ P_0 (x_0 , \, 0, \, 0, \, 0) $ was unstable. The results showed that a latently infected delay and an intracellular delay did not affect the global stability of the model, and numerical simulations were carried out to illustrate the theoretical results.
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