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CHEN Ji-wu, ZHU Zhen-qin, SU Yu, WANG Ni, CAO Jia-qi, LIU Guo-wei, HU Bing, ZHAI Wan-yin. Effects of Procyanidins on Preventing Mitochondria Damage in Rat Liver Induced by •OH[J]. Journal of East China Normal University (Natural Sciences), 2004, (2): 92-96.
Citation:
CHEN Ji-wu, ZHU Zhen-qin, SU Yu, WANG Ni, CAO Jia-qi, LIU Guo-wei, HU Bing, ZHAI Wan-yin. Effects of Procyanidins on Preventing Mitochondria Damage in Rat Liver Induced by •OH[J]. Journal of East China Normal University (Natural Sciences), 2004, (2): 92-96.
CHEN Ji-wu, ZHU Zhen-qin, SU Yu, WANG Ni, CAO Jia-qi, LIU Guo-wei, HU Bing, ZHAI Wan-yin. Effects of Procyanidins on Preventing Mitochondria Damage in Rat Liver Induced by •OH[J]. Journal of East China Normal University (Natural Sciences), 2004, (2): 92-96.
Citation:
CHEN Ji-wu, ZHU Zhen-qin, SU Yu, WANG Ni, CAO Jia-qi, LIU Guo-wei, HU Bing, ZHAI Wan-yin. Effects of Procyanidins on Preventing Mitochondria Damage in Rat Liver Induced by •OH[J]. Journal of East China Normal University (Natural Sciences), 2004, (2): 92-96.
Oxidative damage of the mitochondria plays an important role in generating and developing process of many diseases.Hydroxyl radical (#8226;OH) has been considered an important factor inducing mitochondria damage.Therefore,it has important significance to study and exploit medicines protecting mitochondria damage caused by #8226;OH.We measured effects of procyanidins preventing mitochondria damage induced by#8226;OH using spectrophotometry and fluorescent polarimetry.The results showed that procyanidins increased effectively membrane lipids fluidity of damaged mitochondria,decreased significantly the mitochondria swelling and lipid peroxidation product formation.As a result,procyanidins can maintain the integrity of structure and function of mitochondria.Above results can provide new data for further exploitation of procyanidins.
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