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ZHAO Lan, ZHANG Hong-feng. Inhibitory effects of polysaccharides extracted from phellinus linteus on the proliferation and metastasis of HO-8910PM and Bcap-37(Chinese)[J]. Journal of East China Normal University (Natural Sciences), 2008, (2): 78-84.
Citation:
ZHAO Lan, ZHANG Hong-feng. Inhibitory effects of polysaccharides extracted from phellinus linteus on the proliferation and metastasis of HO-8910PM and Bcap-37(Chinese)[J]. Journal of East China Normal University (Natural Sciences), 2008, (2): 78-84.
ZHAO Lan, ZHANG Hong-feng. Inhibitory effects of polysaccharides extracted from phellinus linteus on the proliferation and metastasis of HO-8910PM and Bcap-37(Chinese)[J]. Journal of East China Normal University (Natural Sciences), 2008, (2): 78-84.
Citation:
ZHAO Lan, ZHANG Hong-feng. Inhibitory effects of polysaccharides extracted from phellinus linteus on the proliferation and metastasis of HO-8910PM and Bcap-37(Chinese)[J]. Journal of East China Normal University (Natural Sciences), 2008, (2): 78-84.
This paper studied the effects and mechanism of polysaccharides extracted from Phellinus linteus on the proliferation and metastasis of HO-8910PM and Bcap-37.The results showed PL inhibited the growth of Bcap37 tumor in vivo by 65.37%, while inhibited the proliferation of HO-8910PM and Bcap-37 in vitro respectively by 15.53% and 23.81%.PL induced G0/G1 phase arrest and 500 ind/ml PL induced HO-8910PM cell apoptosis after 96 h treatments.PL may act as a direct inhibitor of HO-8910PM cell adhesion, invasion and migration which are related to tumor metastasis.The result indicated that PL has inhibitory effect on tumor cell proliferation and metastasis.
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