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Issue 6
Jan.  2013
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QI Long, ZUO Di, WANG Hui, LI Xiao-tao. Expressions of REGγ, p53, NOTCH1 and BRAF gene in thyroid cancer and their clinical relevance[J]. Journal of East China Normal University (Natural Sciences), 2012, (6): 89-95.
Citation: QI Long, ZUO Di, WANG Hui, LI Xiao-tao. Expressions of REGγ, p53, NOTCH1 and BRAF gene in thyroid cancer and their clinical relevance[J]. Journal of East China Normal University (Natural Sciences), 2012, (6): 89-95.

Expressions of REGγ, p53, NOTCH1 and BRAF gene in thyroid cancer and their clinical relevance

  • Received Date: 2012-01-01
  • Rev Recd Date: 2012-04-01
  • Publish Date: 2012-11-25
  • This study was designed to investigate the expressions of〖WTBX〗 REG〖WTBZ〗,〖WTBX〗 〖STBX〗p53〖WTBZ〗, 〖WTBX〗NOTCH1〖WTBZ〗 and 〖WTBX〗BRAF〖WTBZ〗 in papillary thyroid cancer as well as the potential correlations with clinicopathological significance. The expressions of 〖WTBX〗REG〖WTBZ〗,〖WTBX〗 p53〖WTBZ〗,〖WTBX〗 NOTCH1〖STBZ〗〖WTBZ〗 and 〖WTBX〗BRAF〖WTBZ〗 in thyroid cancer samples were detected by Realtime-PCR and immunohistochemistry, respectively. The correlations with clinicopathological factors were statistically analyzed. The expression of 〖WTBX〗REG〖WTBZ〗 in papillary thyroid cancer samples was significantly higher, with an 87.5% (35/40) positive rate in cancer tissues, and was correlated with age and lymph node status (〖WTBX〗P〖WTBZ〗=0.015 10.05), but not related to sex (〖WTBX〗P〖WTBZ〗=0.7420.05). In addition, the 〖WTBX〗REG〖WTBZ〗 had a positive correlation with the levels of 〖WTBX〗〖STBX〗p53, NOTCH1〖STBZ〗〖WTBZ〗 and 〖WTBX〗BRAF〖WTBZ〗 (〖WTBX〗P〖WTBZ〗=0.023 30.05), indicating that 〖WTBX〗REG〖WTBZ〗 could serve as an objective biological-marker for estimating the occurrence and progression of papillary thyroid cancer. Combined detection of 〖WTBX〗〖STBX〗p53〖WTBZ〗,〖WTBX〗 NOTCH1〖WTBZ〗 and 〖WTBX〗BRAF 〖WTBZ〗may facilitate clinical diagnosis, treatment and prediction of prognosis.
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