CYP1A1基因Ile462Val多态位点在吸烟人群中与肺癌易感性显著相关

蔡燕燕; 谭晓明; 郑红霞; 顾海英; 詹晓莹; 吴奇涵

CYP1A1基因Ile462Val多态位点在吸烟人群中与肺癌易感性显著相关

1.
华东师范大学生命科学学院,上海 200062;
2.
第二军医大学附属长征医院,上海 200003

详细信息

中图分类号: R734.2
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出版历程
- 收稿日期: 2010-05-01
- 修回日期: 2010-08-01
- 刊出日期: 2011-07-05

Meta-analysis of CYP1A1 polymorphisms and lung cancer risk among smokers

1.
School of Life Science, East China Normol University, Shanghai 200062, China 2. Changzheng Hospital, Second Military Medical University, Shanghai 200003, China

摘要

摘要: 利用meta分析的方法探讨吸烟人群中CYP1A1基因多态位点与肺癌易感性的关系.获取1986年至2010年2月pubmed等数据库中有关CYP1A1基因Ile462Val和Msp1位点多态性与肺癌易感性关系的研究结果，统计对应的吸烟者或非吸烟者的研究数据，运用RevMan 4.2软件对各研究原始结果进行统计处理，计算合并OR值及95%可信区间.按照纳入标准，最终入选文献共有29篇病例对照研究，吸烟者中Ile462Val位点与肺癌发生显著相关，基因型Val/Val+Ile/Val 比 Ile/Ile的合并OR值为1.29（95%CI∶1.03,1.63），P0.05，而该位点在非吸烟者中及Msp1位点在两种人群的分析结果均不具统计学意义.上述结果提示,对目前相关研究结果的Meta分析显示,吸烟者中CYP1A1基因Ile462Val位点多态性与肺癌易感性之间存在一定相关性.
- 肺癌 /
- CYP1A1基因 /
- 多态性 /
- meta分析
Abstract: All of the publications were eligible from Medline and Pubmed databases and the information about relationship between CYP1A1 Ile462Val and Msp1 polymorphisms and lung cancer risk among smokers was summarized. Meta-analysis was performed using RevMan 4.2. 29 case-control studies were available. For Ile462Val, meta-analysis revealed that the risk of lung cancer among smokers with Val/Val and Ile/Val genotypes was 1.29 times of those with Ile/Ile genotype (P0.05) by the random effects model. There was no significant correlation between Msp1 and lung cancer among smokers or non-smokers. These results suggest that CYP1A1 Ile462Val polymorphism is related to the susceptibility of lung cancer among smokers.
- lung cancer /
- CYP1A1 /
- polymorphisms /
- meta-analysis

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参考文献(1)

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