前脑特异性过表达NR2B基因对小鼠社会互动能力的影响

张宁; 李春霞

前脑特异性过表达NR2B基因对小鼠社会互动能力的影响

张宁¹,
李春霞^1,2

1.
华东师范大学脑功能基因组学教育部重点实验室、上海市脑功能基因组学重点实验室,上海 200062;
2.
华东师范大学认知神经科学研究所,上海 200062

详细信息

中图分类号: Q189
计量
- 文章访问数: 2100
- HTML全文浏览量: 21
- PDF下载量: 2173
- 被引次数: 0
出版历程
- 收稿日期: 2011-04-01
- 修回日期: 2011-07-01
- 刊出日期: 2012-07-25

Effect of forebrain NR2B overexpression on social interactions in transgenic mice

ZHANG Ning¹,
LI Chun-xia^1,2

1.
Key Laboratory of Brain Functional Genomics, Ministry of Education, Shanghai Key Laboratory of Brain Functional Genomics, East China Normal University, Shanghai 200062, China;
2.
Institute of Cognitive Neuroscience, East China Normal University, Shanghai 200062, China

摘要

摘要: 将2～3月龄实验小鼠分为前脑NR2B过表达的转基因雌性和雄性小鼠以及同窝野生对照雌性和雄性小鼠，进行社会互动能力测试，包括新环境中的社会互动能力测试、社会交往能力和社会新奇偏好测试.结果显示，前脑NR2B表达量的提高，对NR2B转基因小鼠在新环境中的社会互动能力和社会新奇偏好无影响.但是却使得雌性NR2B转基因小鼠的社会交往能力提高，但是对雄性NR2B转基因小鼠却无明显影响.这表明，NR2B在前脑过量表达会提高雌性小鼠的社会交往能力，但对于雄性小鼠社会行为没有明显影响.
- NR2B /
- 转基因小鼠 /
- 社会互动 /
- 社会交往能力 /
- 社会新奇偏好
Abstract: Male and female NR2B transgenic mice and their littermate controls were subjected to the social interaction test in a novel environment, sociability test and social novelty test. There was no significant difference in social interaction test in a novel environment and social novelty test among these four groups. However, compared with wild type mice, female but not male NR2B transgenic mice exhibited improvement in sociability. These results suggest that NR2B overexpression in the forebrain can improve sociability of female mice, while having no significant effect on social behaviors in male mice.
- NR2B /
- transgenic mice /
- social interaction /
- sociability /
- social novelty

HTML全文

参考文献(1)

[1]

［1］ KUTSUWADA T, KASHIWABUCHI N, MORI H, et al. Molecular diversity of the NMDA receptor channel［J］. Nature, 1992, 358(6381): 36-41.

［2］ MONYER H, SPRENGEL R, SCHOEPFER R, et al. Heteromeric NMDA receptors: molecular and functional distinction of subtypes［J］. Science, 1992, 256(5060): 1217-1221.

［3］ MOHN A R, GAINETDINOV R R, CARON M G, et al. Mice with reduced NMDA receptor expression display behaviors related to schizophrenia［J］. Cell, 1999, 98(4): 427-436.

［4］ HALENE T B, EHRLICHMAN R S, LIANG Y, et al. Assessment of NMDA receptor NR1 subunit hypofunction in mice as a model for schizophrenia［J］. Genes, brain, and behavior, 2009, 8(7): 661-675.

［5］ PECA J, FELICIANO C, TING J T, et al. Shank3 mutant mice display autistic-like behaviours and striatal dysfunction［J］. Nature, 2011, 472(7344): 437-442.

［6］ TANG Y P, SHIMIZU E, DUBE G R, et al. Genetic enhancement of learning and memory in mice［J］. Nature, 1999, 401(6748): 63-69.

［7］ CAO X, CUI Z, FENG R, et al. Maintenance of superior learning and memory function in NR2B transgenic mice during ageing［J］. The European journal of neuroscience, 2007, 25(6): 1815-1822.

［8］ MATSUO N, TANDA K, NAKANISHI K, et al. Comprehensive behavioral phenotyping of ryanodine receptor type 3 (RyR3) knockout mice:decreased social contact duration in two social interaction tests［J］. Frontiers in behavioral neuroscience, 2009(3): 3.

［9］ MOY S S, NADLER J J, PEREZ A, et al. Sociability and preference for social novelty in five inbred strains:an approach to assess autistic-like behavior in mice［J］. Genes Brain Behav, 2004, 3(5): 287-302.

［10］ NADLER J J, MOY S S, DOLD G, et al. Automated apparatus for quantitation of social approach behaviors in mice［J］. Genes Brain Behav, 2004, 3(5): 303-314.

［11］ TANG A C, NAKAZAWA M, ROMEO R D, et al. Effects of long-term estrogen replacement on social investigation and social memory in ovariectomized C57BL/6 mice［J］. Hormones and behavior, 2005, 47(3): 350-357.

［12］ SANCHEZ-ANDRADE G, KENDRICK K M. Roles of alpha- and beta-estrogen receptors in mouse social recognition memory:effects of gender and the estrous cycle［J］. Hormones and behavior, 2011, 59(1): 114-122.

施引文献

资源附件(0)

访问统计