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Jan.  2012
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XU Hao, WANG Bo, DUAN Yan-hong, CAO Xiao-hua. βCaMKII overexpression impairs long-term depression in dentate gyrus of mice[J]. Journal of East China Normal University (Natural Sciences), 2012, (1): 54-62.
Citation: XU Hao, WANG Bo, DUAN Yan-hong, CAO Xiao-hua. βCaMKII overexpression impairs long-term depression in dentate gyrus of mice[J]. Journal of East China Normal University (Natural Sciences), 2012, (1): 54-62.

βCaMKII overexpression impairs long-term depression in dentate gyrus of mice

  • Received Date: 2011-02-01
  • Rev Recd Date: 2011-05-01
  • Publish Date: 2012-01-25
  • This experiment was designed to investigate the effects of the CaMKII on the long-term depression (LTD) in dentate gyrus(DG)by using the transgenic mice in which the overexpression of CaMKII is restricted to the DG area. Compared to the control group, the paired-pulse depression curve and voltage-current response in DG of transgenic mice didnt change, but the LTD was significantly reduced. These results suggest that overexpression of the CaMKII may impair the long-term depression without effect on the presynaptic function and passive properties of granule cells in DG area.
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