Preparation and properties study of a new type of T1-T2 dual mode MRI contrast agent

GAO Li-peng; LIU Kai; LUO Chun-hua; LI Jian-qi; WANG Yi-ting; PENG Hui

Issue 5

Sep. 2013

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Article Navigation > Journal of East China Normal University (Natural Sciences) > 2013 > (5): 102-109

GAO Li-peng, LIU Kai, LUO Chun-hua, LI Jian-qi, WANG Yi-ting, PENG Hui. Preparation and properties study of a new type of T1-T2 dual mode MRI contrast agent[J]. Journal of East China Normal University (Natural Sciences), 2013, (5): 102-109.

Citation:

GAO Li-peng, LIU Kai, LUO Chun-hua, LI Jian-qi, WANG Yi-ting, PENG Hui. Preparation and properties study of a new type of T1-T2 dual mode MRI contrast agent[J]. Journal of East China Normal University (Natural Sciences), 2013, (5): 102-109.

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Preparation and properties study of a new type of T1-T2 dual mode MRI contrast agent

1.
Institutes for Advanced Interdisciplinary Research, East China Normal University, Shanghai 200062, China;
2.
Key Laboratory of Polar Materials and Devices, Ministry of Education, East China Normal University, Shanghai 200241, China;
3.
Department of physics, East China Normal University, Shanghai 200062, China

Received Date: 2013-03-01
Rev Recd Date: 2013-06-01
Publish Date: 2013-09-25

Abstract

Abstract

This paper studied the Fe3O4 @ SiO2 @ Gd2O(CO3)2 core/shell/shell NPs as a new type of T1-T2 dual model contrast agent for magnetic resonance imaging. The magnetic coupling between Gd2O(CO3)2 and Fe3O4 was modulated by the separating SiO2 layer to produce appropriate T1 and T2 signal. The Fe3O4 @ SiO2 @ Gd2O(CO3)2 NPs exhibit good biocompatibility, showing great potential for biomedical applications.
- Fe3O4 @ SiO2 @ Gd2O(CO3)2 core/shell/shell NPs,
- dual model contrast agent,
- biocompatibility

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References

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